Phenotype-Tailored Lifestyle Intervention for Obesity: A Randomized Trial

Launched by MAYO CLINIC · Jan 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new approach to help people with obesity lose weight and keep it off. The researchers want to find out if a personalized lifestyle program, tailored to each person's specific needs, can lead to better weight loss results. The study is currently recruiting participants aged 18 to 65 who have a body mass index (BMI) over 30, which means they are considered obese. However, people with certain conditions, like recent significant weight changes, a history of weight-loss surgeries, or untreated mental health issues, cannot participate.

If you qualify and decide to join, you can expect to take part in a program that focuses on lifestyle changes designed just for you. This might include guidance on diet, exercise, and other healthy habits. The goal is not only to help you lose weight but also to support you in maintaining that weight loss over time. It's important to know that this trial seeks to create a more effective and scientific way to tackle obesity, and your involvement could contribute to better strategies for others facing similar challenges.

Gender

ALL

Eligibility criteria

• Inclusion:
• • • men or women between 18 to 65 years with obesity (BMI\>30kg/m2).
• Exclusion:
• • weight change greater than 3% in the previous 3 months
• • history of bariatric surgery and bariatric endoscopy
• • untreated psychiatric disorders including binge eating disorders and bulimia
• • current use of AOMs
• • history of use of medications affecting weight or energy intake or energy expenditure in the last 6 months
• • history of type 1 diabetes mellitus or uncontrolled medical conditions (e.g., uncontrolled hypertension)
• • women who are pregnant or plan to become pregnant,
• • any condition that limits their participation in the study
• • Principal Investigator discretion