Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study

Launched by MAYO CLINIC · Jan 9, 2025

Keywords

ClinConnect Summary

This clinical trial is looking into how doctors can better understand the heart's condition, especially in patients with a problem called mitral regurgitation, which affects how blood flows through the heart. The study aims to see if using advanced imaging techniques like cardiac CT and MRI can help identify patients at risk for a specific heart issue known as left ventricular systolic dysfunction. This research is a preliminary step to gather information for a larger study in the future.

To be eligible for this trial, participants need to be at least 18 years old and diagnosed with severe, chronic mitral regurgitation. They should be planning to undergo a specific heart surgery called robotic mitral annuloplasty at the Mayo Clinic in Rochester. It’s important that participants can understand and agree to be part of the study or have someone who can help them make that decision. During the trial, participants will undergo imaging tests to monitor their heart health, and the study is currently looking for volunteers. If you or someone you know meets these criteria, this could be an important opportunity to contribute to heart health research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \>= 18
• • Male or Female
• • A diagnosis of severe chronic primary mitral regurgitation
• • Undergoing isolated robotic mitral annuloplasty at Mayo Clinic Rochester
• • Patients must have the ability to consent or have an appropriate representative available to do so.
• Exclusion Criteria:
• • Prior valve intervention,
• • Concomitant valve surgery at the time of mitral annuloplasty (e.g. tricuspid annuloplasty, aortic valve replacement).
• • Concomitant \>= moderate regurgitation or stenosis in any other valve by preoperative echocardiography
• • History of prior myocardial infarction
• • History of cardiomyopathy unrelated to mitral regurgitation (e.g. dilated, hypertrophic, infiltrative)
• • Pregnancy. Women of childbearing potential will be verbally screened by clinical staff during as part of routine pre-MRI evaluation. If a subject is unsure whether they could be pregnant, a negative pregnancy test will be performed prior to scanning.
• • Implantable devices that would be a contraindication to MRI
• • Severe allergy to gadolinium MRI contrast