Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins

Launched by XIAGUANG DUAN · Jan 10, 2025

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ClinConnect Summary

This clinical trial is studying whether a type of anesthesia called desflurane might cause memory and thinking problems after surgery in older patients. The researchers want to find out if using desflurane is linked to these cognitive issues, especially by looking at certain proteins in the blood that may play a role. To do this, they will give desflurane to elderly patients who are scheduled for elective surgeries and then check their cognitive function a couple of days later using a simple assessment test.

To be part of this study, participants must be over 70 years old, generally healthy, and able to give their consent and understand the study procedures. They should not have any serious brain or psychiatric conditions that could affect their thinking. If eligible, participants will receive desflurane during surgery and will have their cognitive function and blood protein levels assessed afterward. It's important to note that this study is not yet recruiting participants, so there will be more information available once it starts.

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Eligibility criteria

• Inclusion Criteria:
• • Age \> 70 years
• • American Society of Anesthesiologists (ASA) physical status classification I-III
• • Scheduled to undergo elective surgery requiring general anesthesia with desflurane
• • Able and willing to provide voluntary written informed consent
• • Able to understand the study procedures and complete follow-up assessments
• Exclusion Criteria:
• • Pre-existing diagnosis of dementia or any other neurodegenerative disease that could affect cognitive function
• • Preoperative Montreal Cognitive Assessment (MoCA) score \< 20
• • History of severe psychiatric disorders, including psychosis, severe depression, or bipolar disorder
• • Unstable angina, uncontrolled hypertension, or a history of myocardial infarction within the past 6 months
• • Severe chronic obstructive pulmonary disease (COPD) with significant respiratory compromise, or other significant respiratory disease
• • Severe hepatic or renal impairment, defined as Child-Pugh class C for liver disease, or glomerular filtration rate (GFR) \< 30 mL/min/1.73 m2 for kidney disease
• • History of stroke, transient ischemic attack (TIA), or other significant neurological disorders
• • History of alcohol or drug abuse
• • Patients with visual, auditory, or language impairments that would interfere with cognitive testing.
• • Known allergy or contraindication to any of the study drugs
• • Other conditions at the discretion of the investigator that could interfere with the conduct of the study or the interpretation of the results