Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy

Launched by CAIRO UNIVERSITY · Jan 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different methods of anesthesia for patients undergoing emergency surgery called laparotomy. The researchers want to find out if using lidocaine, a local anesthetic, is better for maintaining stable blood pressure compared to the traditional use of opioids, which are stronger pain medications. Opioids can cause side effects and may lead to low blood pressure, especially in patients who already have health issues. The goal is to see if lidocaine can provide a safer and more effective option for anesthesia during these surgeries.

To be eligible for this trial, participants must be adults between the ages of 18 and 99 who are classified as having mild to moderate health issues (ASA class I-III) and are scheduled for an emergency laparotomy. However, anyone with severe heart problems, low blood pressure, or those who are pregnant or breastfeeding cannot participate. If you choose to join the study, you will receive either the lidocaine or opioid-based anesthesia, and the medical team will monitor your vital signs closely throughout the procedure to ensure your safety and comfort.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Adult patients
• • 2. Both gender
• • 3. American Society of Anesthesiologists (ASA) class I-III undergoing emergency laparotomy.
• Exclusion Criteria:
• • 1. Patient refusal
• • 2. Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions)
• • 3. Baseline mean arterial pressure \<75 mmHg
• • 4. Patients on vasopressor infusion,
• • 5. Patients with high shock index (heart rate / systolic blood pressure \>1)
• • 6. Pregnant or lactating women,
• • 7. Allergy of any of the study drugs
• • 8. Hypertensive patients and patients on beta blockers.
• • 9. Uncontrolled hypertensive patients or patients receiving angiotensin converting enzyme (ACE) inhibitors preoperatively.
• • 10. Opioid drug abusers.
• • 11. Patients with increased intracranial tension.