Cognitive Reappraisal Training for Borderline Personality (BPD)

Launched by ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · Jan 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment approach for people with Borderline Personality Disorder (BPD). The researchers believe that a technique called cognitive reappraisal training, specifically "reappraisal-by-distancing," can help patients manage their emotions better. The goal is to see if this training can positively affect both brain activity and behavior, and ultimately improve the quality of life for those living with BPD.

To participate in this trial, individuals must be between 18 and 55 years old and diagnosed with BPD. They should be in good health and able to give informed consent. However, those with certain other mental health conditions, like severe depression or specific personality disorders, cannot take part. Participants will have the opportunity to engage in this training, and they may also continue their current medications or therapy as long as there have been no changes in the past two months. This study is currently recruiting participants of all genders and backgrounds.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Medically healthy men and women with Borderline Personality Disorder who are mentally competent and give informed voluntary written consent.
• • Participants will be between the ages of 18 and 55.
• • Within these requirements, the inclusion and exclusion criteria do not reflect participation based on gender or racial/ethnic group. The targeted/planned enrollment is a reflection of previous recruitment of female and ethnic minorities in other studies conducted by the PI and their colleagues and includes representations of both genders and all minorities.
• Exclusion Criteria:
• • Participants will not meet criteria for Schizotypal Personality Disorder or Avoidant Personality Disorder.
• • Participants currently meeting criteria for Major Depressive Disorder will be excluded.
• • BPD participants will not meet DSM-5 criteria for past or present PTSD, bipolar I disorder, schizophrenia, schizoaffective disorder, substance use disorder within the past 6 months, organic mental syndromes, head trauma, schizotypal personality disorder, avoidant personality disorder, CNS neurological disease, or seizure disorder. Participants meeting criteria for a non-IV substance use disorder more than 6 months prior to enrollment will not be excluded. This study allows patients who are currently taking psychotropic medications or are in psychotherapy, so long as there has been no change in medication or psychotherapy over the preceding two months.
• • Participants currently meeting criteria for major depressive disorder.
• • Participants meeting criteria for substance use disorder within the last 6 months or of an IV-substance use disorder at any time.
• • Participants may not have a pacemaker, surgical clips, any metallic implants, or shrapnel fragments that would contraindicate MRI scanning.
• • Pregnant women.