Associations Between Dietary Intake and Cardiometabolic and Gut Microbiota Outcomes

Launched by NATIONAL UNIVERSITY OF SINGAPORE · Jan 9, 2025

Keywords

ClinConnect Summary

This clinical trial is looking to understand how what we eat affects our heart health, gut bacteria, and other important health factors in adults living in Singapore. Researchers want to see if there are any connections between diet and issues like heart disease risk, gut health, skin conditions, cognitive abilities, and sleep quality.

To participate in this study, you need to be between 21 and 80 years old, able to read and understand English, and willing to give consent. You should also have stable health without significant diet changes in the past year and have been consistently taking certain medications for conditions like high blood pressure or diabetes for more than five years. Participants will not be able to take specific dietary supplements or fermented foods for a certain period before the study visits, as these could affect the results. If you join, you'll help researchers learn more about how diet impacts overall health, which could lead to better health advice for everyone.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Able to give informed consent
• • 2. Adults 21-80 years old
• • 3. English-literate
• • 4. Have venous access sufficient to allow for blood sampling as per the protocol
• • 5. No drastic change of diet for the past 1 year
• • 6. If taking medication, has been consistently taking antihypertensive/cholesterol-lowering/type-2 diabetic medication for more than 5 years prior to starting the study.
• Exclusion Criteria:
• • 1. Taking dietary supplements and fermented foods, which may impact the gut microbiota (e.g. antibiotics, prebiotics, probiotics, yogurt, kimchi) 2 months before starting the 1st study visit only.
• • 2. Taking dietary supplements or medications, which may impact sleep outcomes (e.g. Nutritional Shakes (e.g. Ensure), tryptophan, 5-hydroxytryptophan or melatonin supplementations) 1 month before starting the study.
• • 3. Taking dietary supplements which may impact the eye outcomes (e.g. Vitamin A, vitamin A-containing multivitamin) 2 months before starting the study.