The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function

Launched by THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY · Jan 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how two common anesthesia medications, remimazolam and propofol, affect patients' brain function and daily rhythms after surgery. The researchers want to see if using remimazolam can help patients recover better and avoid problems with thinking clearly after their surgery compared to those receiving propofol. The trial will involve patients aged 18 to 65 who are scheduled for a specific type of surgery called laparoscopic cholecystectomy, which typically takes about 1.5 to 2.5 hours.

To participate, individuals must meet certain criteria, including having a stable weight and a good mental status before surgery. They should not have serious health issues or a history of substance abuse. Participants will receive either remimazolam or propofol during their procedure, and the study aims to monitor their recovery and cognitive function afterward. Overall, this trial is an important step toward understanding how different anesthetics can affect patient outcomes after surgery.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Age 18-65 years old, ASAI-III class, BMI18.5-25kg/m2 Inpatients undergoing laparoscopic cholecystectomy The estimated time of operation is 1.5\~2.5 hours Preoperative brief mental status examination (MMSE) score ≥24 Voluntary participation and signed informed consent
• Exclusion Criteria:
• • Pregnant or lactating women Patients who are allergic to remimazolam or contraindicated Patients who are dependent on or tolerant to opioids or have long-term alcoholism Serious cardiovascular system, respiratory system, liver and kidney diseases History of obstructive sleep apnea mental disorders or neurological diseases Patients who participated in clinical trials of other drugs within the last 3 months The attending physician or researcher considers that there are other circumstances that are not suitable for participation in this study Refuse to participate in the study