Ultrasound Contrast-Enhanced Accurate Diagnosis of Preoperative Staging of Bladder Cancer

Launched by SUN YAT-SEN MEMORIAL HOSPITAL OF SUN YAT-SEN UNIVERSITY · Jan 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new method for accurately diagnosing the stage of bladder cancer before surgery using a special ultrasound technique called contrast-enhanced ultrasound (CEUS). The goal is to improve the way doctors assess how advanced the cancer is, which is important for making treatment decisions. Preliminary results have shown that this method is quite effective, with high accuracy in identifying the cancer stage. The study will also explore combining CEUS with MRI (another imaging technique) to further enhance diagnostic precision.

To participate in this trial, individuals must be at least 18 years old and have a confirmed diagnosis of primary bladder cancer. It's important that they have not received any prior treatments like surgery or chemotherapy before the ultrasound procedure. Participants can expect to undergo the ultrasound examination and, if they qualify, contribute to developing a better diagnostic system for bladder cancer. This research aims to provide clearer information for doctors and improve care for patients facing bladder cancer.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • (a) eligible patients should be 18-year-old or older;
• • (b) patients should have a histologically or cytologically confirmed diagnosis of primary bladder cancer;
• • (c) patients should not have had any surgery, chemotherapy, immunotherapy, or any therapy before CEUS diagnosis.
• Exclusion Criteria:
• • (a) participants with confirmed to have no carcinoma of the bladder;
• • (b) participants with previous pelvic surgery, who had undergone therapy, any bladder surgery, or had received chemotherapy, radiotherapy or immunotherapy;
• • (c) participants diagnosed with tumor recurrence or metastasis; (d) participants who were allergic to ultrasound contrast agents or could not tolerate CEUS examination, for instance, with recent myocardial infarction, angina pectoris, cardiac insufficiency, severe cardiac arrhythmia, a right/left cardiac shunt, severe pulmonary hypertension, uncontrolled systemic hypertension, acute respiratory distress syndrome, or chronic obstructive pulmonary disease.