Physical Activity and Insulin Sensitivity Dynamics

Launched by UNIVERSITY OF COPENHAGEN · Jan 9, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring how a single session of exercise can improve the way muscles respond to insulin, which helps regulate blood sugar levels. Specifically, the study will look at how quickly insulin starts to work in the muscles after exercise. The researchers will focus on young, healthy men who will perform a specific type of leg exercise, followed by a procedure that helps them understand how insulin is signaling in the body.

To be eligible to participate, men aged 22 to 35 must be healthy, not taking any medications, and should not smoke. They should also have a moderate level of fitness and a body mass index (BMI) between 28 and 35. Participants can expect to engage in a leg exercise and will be closely monitored to see how their muscles respond to insulin afterward. The study is currently recruiting, and it aims to provide valuable insights into how exercise can enhance insulin sensitivity in muscles.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Healthy individuals (no known diseases)
• • No use of medication
• • Non-smokers
• • Male
• • Aged 22-35 years
• • Fitness level (VO2max, i.e., maximal oxygen uptake) between 30-50 mL O2/min/kg
• • BMI between 28 and 35
• Exclusion Criteria:
• • Women
• • Failure to meet all inclusion criteria
• • Physical activity level (e.g., running, cycling, fitness, etc.) exceeding 6 hours per week
• • Acute illness within 2 weeks prior to the study days
• • Use of recreational drugs within 2 weeks prior to the study days