Visual (Path)Ways in Multiple Sclerosis - Part II

Launched by UNIVERSITY HOSPITAL, LILLE · Jan 9, 2025

Keywords

ClinConnect Summary

The clinical trial titled "Visual (Path)Ways in Multiple Sclerosis - Part II" is investigating how multiple sclerosis (MS) affects vision and the underlying processes that lead to vision problems in people with this condition. MS can cause inflammation and damage in the central nervous system, which can result in visual impairment. This study aims to understand the mechanisms behind these vision issues by examining different aspects of the visual pathways over time.

To participate in this trial, individuals should be at least 18 years old and have relapsing-remitting MS, meaning their symptoms come and go. They should also be receiving treatment for their MS and have previously participated in the VWIMS study at Lille University Hospital. Participants can expect to undergo various tests and procedures to help researchers gather important data about vision in MS. It's important to note that certain individuals, such as those with other specific eye or neurological conditions, pregnant or nursing women, or those unable to give consent, may not be eligible for this study.

Gender

ALL

Eligibility criteria

• • Patients with relapsing-remitting multiple sclerosis receiving high-efficacy or non-high-efficacy treatment and follow-up at the CRCSEP of the Lille University Hospital through past participation in the VWIMS study.
• Inclusion criteria:
• • Male and/or female participants in the VWIMS research project
• • At least 18 years of age at the time of inclusion in VWIMS - II
• • Patient having given written consent to participate in the study
• • Socially insured patient
• • Patient willing to comply with all study procedures and duration
• Exclusion Criteria:
• • Age \< 18 years
• • Other neurological pathologies that may interfere with MRI and/or OCT data (diabetes, retinopathy \[any cause\], glaucoma, retinal detachment, ametropia \> 6 diopters)
• • Contraindications to MRI (claustrophobia, incompatible metal foreign bodies such as certain pacemakers and mechanical valves, cochlear implants, intra-orbital metal splinters, pregnancy, certain brands of IUD because of the 3 Tesla magnetic field).
• • Contraindication to injection: severe renal failure with creatine clearance \<30, allergy to contrast media, pregnancy, breast-feeding.
• • Pregnant women
• • Nursing women
• • Persons incapable of giving consent on their own, with or without legal protection (guardianship/curatorship)
• • Person under legal protection
• • Persons deprived of their liberty
• • Administrative reasons: inability to receive informed information, inability to participate in the entire study, lack of social security coverage, refusal to sign consent form