A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Subjects with Type 2 Diabetes Mellitus and Poor Blood Glucose Control by Diet and Exercise

Launched by GAN & LEE PHARMACEUTICALS. · Jan 10, 2025

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ClinConnect Summary

This clinical trial is studying a new treatment called GZR18 Injection for people with Type 2 Diabetes Mellitus (T2DM) who are having trouble controlling their blood sugar levels through diet and exercise alone. The goal is to see if this injection is safe and effective for managing blood sugar in Chinese adults aged 18 and older. To participate, you need to have been diagnosed with T2DM for at least eight weeks and be willing to follow a regular diet and exercise plan during the study.

Participants in the trial will be required to understand the purpose of the study and be able to communicate with the research team. It’s important to note that people with certain health conditions, allergies to similar medications, or a recent history of serious medical issues may not be eligible to join. This study is not yet recruiting, but it aims to provide valuable information on how GZR18 Injection could help those struggling with diabetes management.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 (as of the date of signing the Informed Consent Form (ICF)), male or female.
• • 2. T2DM is diagnosed for at least 8 weeks according to the diagnostic criteria of diabetes mellitus issued by the World Health Organization (WHO) in 1999 and the supplementary diagnostic criteria of WHO in 2011 (HbA1c diagnosis is recommended).
• • 3. No birth plan from the signing of ICF to 8 weeks after the last dose, willingness to use effective methods of contraception, and no plan for sperm donation. Females of childbearing potential must not be lactating and must have negative results of pregnancy tests at screening and baseline.
• • 4. Fully understand the purpose, nature, methods, and possible adverse drug reactions (ADRs) of the study, be able to communicate well with the investigator, can understand and comply with the requirements specified in this study, can maintain a regular diet and exercise lifestyle during the study, and voluntarily sign the ICF to enter the study.
• • -
• Exclusion Criteria:
• • 1. Poor compliance during the run-in period as assessed by the investigator.
• • 2. Known or suspected to be allergic to GLP-1R agonists or their excipients, or have contraindications to their use.
• • （3)Systolic blood pressure (SBP) ≥ 160 mmHg or diastolic blood pressure (DBP) ≥ 100 mmHg at screening or before randomization (concomitant antihypertensive drugs are allowed).
• • （4）Have the following cardiovascular and cerebrovascular diseases within 6 months before screening: Decompensated cardiac insufficiency (New York Heart Association NYHA Class III or IV), angina unstable or myocardial infarction, history of heart valve replacement surgery, coronary artery bypass grafting or other invasive cardiovascular surgery including percutaneous coronary intervention, ischemic or hemorrhagic stroke (excluding lacunar infarction), or transient ischemic attack.
• • （5）History or relevant family history of medullary thyroid cancer, multiple endocrine neoplasia (MEN) 2A or 2B before screening.
• • （6）History of malignant tumors before screening (excluding adequately treated or resected non-metastatic basal or squamous cell skin cancer, cervical carcinoma in situ, or prostate cancer in situ) or the presence of underlying malignancy at screening.
• • （7）Participated in any drug clinical study (received non-placebo medication during the study) within a period of time before randomization (90 days or 5 half-lives of the previous IMP, whichever is longer), or plan to participate in another clinical study before completing all scheduled assessments in this clinical study.
• • （8）Subjects with any other factors that may affect the efficacy or safety evaluation of this study as judged by the investigator.-