COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children

Launched by AMERICAN UNIVERSITY OF BEIRUT MEDICAL CENTER · Jan 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how certain genetic factors may affect pain levels in children after surgery. Specifically, researchers want to find out if changes in two genes, OPRM1 and COMT, influence how much pain children experience after they have orthopedic, abdominal, thoracic, or plastic surgeries. The study is looking for children aged 8 to 18 who are healthy enough for surgery (classified as ASA I, II, or III) to participate.

If eligible and you choose to participate, your child will be monitored for their pain levels, how sleepy they feel, the amount of pain relief medicine they need, and how long they stay in the recovery area after surgery. This research could help doctors understand how to better manage pain for children based on their genetic makeup. It's important to note that children with certain mental health conditions or who will receive specific types of anesthesia may not be able to participate in the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All children 8 years to 18 years
• • Undergoing orthopedic, abdominal, thoracic, and plastic surgeries
• • American Society of Anesthesiologists classification (ASA) I-II-III
• Exclusion Criteria:
• • Children with schizoid personality disorders, phobias, and anxiety
• • Patients with neuropathic pain associated with surgeries requiring surgical treatment.
• • Children presented with all types of depressive disorders, atypical bipolar disorder, or a suspicion of substance abuse.
• • American Society of Anesthesiologists classification (ASA) ≥IV
• • All patients receiving regional anesthesia, local blocks, epidural and caudal blocks.