Frequency and Predictors of Recurrent SBP in Cirrhotic Patients in Al Rajhi University Hospital

Launched by ASSIUT UNIVERSITY · Jan 12, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a condition called Spontaneous Bacterial Peritonitis (SBP), which can occur in patients with liver cirrhosis. The main goals of the study are to find out how often SBP comes back after a first episode and to identify factors that may help predict whether a patient will experience a recurrence. This research is being conducted at Al Rajhi University Hospital and aims to better understand this serious condition to improve patient care.

To participate in the trial, patients must be at least 18 years old and have been diagnosed with cirrhosis and a first episode of SBP. This diagnosis is typically confirmed through physical symptoms, lab tests, and imaging studies. However, patients who have certain other types of bacterial infections in their abdominal fluid or those who have complications from surgery will not be included. Although the trial is not yet recruiting participants, it is important for eligible patients to know that their involvement could contribute valuable information to help others facing similar health challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Any cirrhotic patient above the age of 18 years old of both sexes, having a first episode of SBP will be included in our study.
• • 1. The diagnosis of cirrhosis was based on clinical manifestation (ascites, splenomegaly, lower limb edema and/or esophageal varices by upper gastrointestinal endoscopy), laboratory findings and radiological (abdominal ultrasonography), or liver histology.
• • 2. The diagnosis of SBP was based on a neutrophil cell count of 250 cell or more per mm3 with or without culture positivity of ascitic fluid, in the absence of hemorrhagic ascites and secondary peritonitis.
• Exclusion Criteria:
• * Any patient with one or more of the following criteria will be excluded:
• • 1. Patients with bacterial ascites defined by a positive culture of ascitic fluid associated with a neutrophil cell count less than 250 cell per mm3 in the ascitic fluid.
• • 2. Patients presenting with empyema or bacterial peritonitis secondary to an intra-abdominal organ perforation or surgical operation