Etiology and Prognostic Analysis of Acute Liver Failure in Chinese Children

Launched by LIYUMEI · Jan 12, 2025

Keywords

ClinConnect Summary

This clinical trial is focused on understanding the causes and outcomes of acute liver failure in children, a serious condition where the liver suddenly stops working properly. The research aims to identify different factors that can lead to this condition and how various treatment options may affect a child's recovery. By studying these aspects, the trial hopes to improve how doctors diagnose and treat pediatric acute liver failure, ultimately enhancing care for affected children and helping to make better decisions about liver transplants when needed.

To participate in this study, children must be diagnosed with acute liver failure, which involves having severe liver problems within the last eight weeks and specific blood clotting issues that cannot be corrected with vitamin K. Eligible children must be under 18 years old, and their legal guardians will need to provide written consent for participation. The trial is not yet recruiting participants, but once it begins, families can expect to contribute valuable information that could lead to better treatments and outcomes for children facing this serious health challenge.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• 1. According to the diagnostic criteria for PALF, the following conditions must be met:
• • ① Severe biochemical liver abnormalities occurring within 8 weeks;
• • ② Coagulation disorders uncorrectable by vitamin K: if hepatic encephalopathy is present, prothrombin time (PT) \> 15s or international normalized ratio (INR) \> 1.5; regardless of the presence of hepatic encephalopathy, PT \> 20s or INR \> 2.0.
• • 2. For patients who were admitted twice, only the information from the first hospitalization will be used.
• • 3. Patients with a history of chronic liver disease (e.g., genetic metabolic factors, drug-induced factors) or biliary obstruction that led to the acute episode are categorized under acute liver failure.
• • 4. The child's legal guardian has signed a written informed consent form.
• Exclusion Criteria:
• • 1. Age \> 18 years;
• • 2. Significant data missing (\>10%);
• • 3. The child's legal guardian refuses participation.