Dexmedetomidine and Dexamethasone Added as Adjuvant Infraclavicular Brachial Plexus Block in Upper Limb Surgery

Launched by UMRANIYE EDUCATION AND RESEARCH HOSPITAL · Jan 12, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how adding two medications, dexmedetomidine and dexamethasone, to a specific type of nerve block called an infraclavicular block can improve pain management for people undergoing surgery on their upper limbs. The researchers want to see if these medications can help the nerve block start working faster, last longer, and reduce the time until patients feel they need pain relief after surgery.

To participate in this trial, individuals must be between 18 and 70 years old and generally healthy (classified as ASA I-II, which means they have no serious health issues). Unfortunately, people with certain conditions, like serious heart or lung problems, specific nerve injuries, or those who are pregnant, cannot join. Participants can expect to receive the nerve block before their surgery and will be monitored to see how well it works in managing their pain. This study is currently recruiting participants and aims to improve postoperative pain control for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18-70 years
• • ASA I-II
• Exclusion Criteria:
• • Under 18 years of age and older than 70 years of age,
• • presence of brachial plexus injury,
• • patients with bleeding diathesis,
• • presence of allergy, -contralateral diaphragmatic paralysis, -
• • presence of nerve injury secondary to trauma,
• • pre-existing neuropathy of the surgical extremity,
• • presence of severe pulmonary,
• • renal and hepatic disease,
• • congestive heart failure (NYHA stage 3-4),
• • uncontrolled diabetes mellitus,
• • history of neuromuscular disease,
• • patients with extreme obesity or malnutrition (BMI \> 30 kg-1m2 or BMI \<20 kg-1m2),
• • presence of epilepsy,
• • history of peripheral vascular disease,
• • history of chronic pain or fibromyalgia,
• • pregnant and lactating patients,
• • patients with local infection at the injection site,
• • patients undergoing general anesthesia due to inadequacy of the block,
• • patients refusing to give informed consent,
• • history of recreational substance use, and chronic narcotic-based painkillers