Efficacy and Safety of Liposomal Bupivacaine and Ropivacaine in Upper Limb Surgery

Launched by XIAGUANG DUAN · Jan 13, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two types of pain relief medications, liposomal bupivacaine and ropivacaine, to see how well they work in managing pain for patients undergoing surgery on their upper limbs, such as for burn injuries, fractures, or procedures like digital replantation. The main goal is to find out if these medications can help reduce the amount of pain relief medicine needed after surgery compared to using general anesthesia alone. Participants will be randomly assigned to receive either a specific nerve block with one of the medications combined with general anesthesia or just general anesthesia by itself.

To participate in this study, you need to be at least two years old and have a specific upper limb injury that requires surgery. You should be in generally good health, as determined by a standard classification system used by anesthesiologists. However, certain conditions, such as allergies to local anesthetics or severe health issues, may prevent you from participating. If you join the trial, your vital signs and pain management needs will be closely monitored after the surgery to ensure your safety and comfort. This study is not yet recruiting participants, but it aims to provide valuable information about pain management options for upper limb surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: Two years or older.
• • ASA Physical Status: American Society of Anesthesiologists (ASA) physical status classification of I, II, or III.
• • Surgical Indication: Patients requiring surgical treatment for any of the following upper limb injuries: Burn injuries. Digital replantation. Upper limb fractures, including fractures of the radius, ulna, humerus, and carpal bones. Hand fractures, including fractures of the phalanges and metacarpals.
• • Patients scheduled to undergo either a continuous brachial plexus block combined with general anesthesia or general anesthesia alone.
• • Patients (or their legal guardians) provided voluntary written informed consent.
• Exclusion Criteria:
• • Known allergy to local anesthetic agents.
• • Presence of infection or skin disease at the planned puncture site.
• • Severe coagulation disorders or current use of anticoagulant medications that cannot be safely discontinued for the procedure.
• • Presence of severe cardiopulmonary or neurological disease.
• • Inability to cooperate with regional or general anesthesia.
• • Pregnancy or lactation.
• • Presence of severe psychiatric illness or cognitive impairment that would hinder participation.
• • Long-term use of analgesic medications.