Clinical Study of HRS-2129 for Postoperative Analgesia in Orthopaedics

Launched by SHANDONG SUNCADIA MEDICINE CO., LTD. · Jan 13, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new medication called HRS-2129 to help manage pain after orthopedic surgery, which includes surgeries related to bones and joints. The main goal is to see if HRS-2129 is safe and effective for relieving pain in patients who have undergone elective orthopedic procedures. The trial is currently recruiting participants aged 65 to 74 who are able to give their consent and are scheduled for surgery.

To be eligible for this study, participants should not have a history of severe allergies, certain nervous system or mental health issues, or problems with their liver or kidneys. They should also have stable blood pressure and no serious heart conditions. If you join the trial, you will receive the medication and be monitored closely by healthcare professionals to ensure your safety and to assess how well the medication works for pain relief. This study is an important step in finding better ways to manage pain after surgery, which can significantly improve recovery and quality of life for patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Able and willing to provide a written informed consent
• • 2. Subjects requiring elective orthopedic surgery
• • 3. Conform to the ASA Physical Status Classification
• Exclusion Criteria:
• • 1. Subjects with a history of severe allergies
• • 2. Subjects with nervous system disease
• • 3. Subjects with a history of mental illness
• • 4. Subjects with abnormal liver and renal function
• • 5. Subjects with poorly controlled hypertensive or hypotensive
• • 6. QTc：\>450ms（male），\>470ms（female）
• • 7. Subjects who screened positive for substance abuse
• • 8. History of cardiac dysrhythmias requiring anti-arrhythmia treatment(s)
• • 9. The investigators determined that other conditions were inappropriate for participation in this clinical trial