Supplemental High Flow Oxygen to Reduce Infections in Obese Gynecological Cancer Patients

Launched by NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS · Jan 15, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at whether giving extra oxygen to obese women with gynecological cancer can help reduce the number of infections and complications after surgery. Surgical-site infections (SSIs) can occur in 10-20% of these patients, which can lead to longer hospital stays and increased medical costs. The idea is that by increasing the amount of oxygen they breathe during and after surgery, it may help their wounds heal better.

To participate in this trial, women need to be obese (with a body mass index or BMI over 30) and have stable blood test results before surgery. They should also have had a break of more than three weeks since their last cancer treatment if they received any. However, this trial is not for women who have a weakened immune system, an existing infection in the abdomen, or a serious infection in the body. If eligible, participants can expect to receive supplemental oxygen during their hospital stay and will help researchers learn more about its effects on healing after surgery.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Obese (BMI\>30kg/m2) gynecological cancer patients
• • Optimized preoperative CBC values (hemoglobin \>11g/dl, WBC 4.000-11.000 X 109/L, platelets 150,000 to 400,000 X 109/L)
• • In the case of neoadjuvant therapy an interval longer than three weeks between the last cycle and the operation
• Exclusion Criteria:
• • Active immunosuppresion
• • Preexisting infection of the abdominal wall
• • Preexisting sepsis