Analysis of the Epidemiology, Clinical Presentation and Therapy as Well as Therapy-associated Risk of Demyelination Syndrome in Patients With Profound Hyponatremia in the Emergency Department

Launched by UNIVERSITY OF COLOGNE · Jan 15, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a condition called hyponatremia, which occurs when sodium levels in the blood are dangerously low. Hyponatremia can lead to serious health issues, including swelling of the brain, which can cause symptoms like confusion, seizures, and even coma. The trial aims to understand how many patients with severe symptoms already have brain swelling when they arrive at the emergency department and whether they develop a serious complication known as osmotic demyelination syndrome (ODS) during their hospital stay. By gathering this information, researchers hope to improve treatment guidelines for patients with profound hyponatremia.

To participate in this study, you must be an adult aged 18 or older and have a sodium level of 125 mmol/L or lower when you first arrive at the emergency department. If you join the trial, you can expect to undergo a series of assessments, including follow-up blood tests to monitor your sodium levels. The study is currently recruiting participants, and your involvement could help doctors better understand how to safely manage hyponatremia and its associated risks.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients ≥18 years
• • Plasma sodium ≤125 mmol/L in the initial blood sample after admission to the Emergency Department
• Exclusion Criteria:
• • Lack of follow-up sodium analyses within the first 24 hours after admission
• • initial blood glucose \>300 mg/dL