Investigation of Objective Cognitive Effort in Neuropsychological Evaluation of Psychotic Disorders

Launched by UNIVERSITY HOSPITAL, MONTPELLIER · Jan 17, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how people with psychotic disorders, like schizophrenia, think and process information, especially when it comes to the effort they put into tasks. Researchers want to understand how motivation and psychological factors, such as mood and anxiety, affect cognitive performance (how well someone thinks and remembers). By comparing individuals with psychotic disorders to those without any mental health issues, the study aims to shed light on whether cognitive problems in these patients are mainly due to their mental health condition or their motivation to engage in tasks.

To participate in this study, individuals should be between 18 and 60 years old. Those with a diagnosis of schizophrenia or other psychotic disorders can join the study, while individuals without any psychiatric disorders will be part of the non-clinical group. Participants will complete memory tasks while their heart rate and other measures are monitored to see how much effort they are putting in. This research is important as it could help improve understanding of cognitive challenges in psychotic disorders and lead to better support and treatments for those affected.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria in both groups
• • - Age ≥ 18 years and ≤60 years
• Inclusion criteria for the psychotic disorders group:
• • - Patients with a diagnosis within the schizophrenia spectrum and other psychotic disorders according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; APA, 2015).
• Inclusion criterion for the non-clinical group:
• • - Absence of any psychiatric disorder.
• • non-inclusion criteria in both groups
• • Neurological disorder or history of head trauma;
• • Cardiovascular disease or treatment for hypertension;
• • Substance abuse or dependence disorder;
• • Individuals who cannot understand or speak French;
• • Non-affiliation with a social security system;
• • Individuals participating in another study that includes an ongoing exclusion period;
• • Individuals who have not provided written informed consent to participate in the study;
• • Pregnant or breastfeeding women;
• • Absence of written consent from the legal guardian for patients under guardianship;
• • Absence of notification to the curator for patients under curatorship.