The Effect of High Single Dose of Dexamethasone in Prevention of Post-operative Acute Kidney Injury in Cardiac Surgeries Requiring Cardiopulmonary Bypass

Launched by AIN SHAMS UNIVERSITY · Jan 15, 2025

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ClinConnect Summary

This clinical trial is studying whether a single high dose of a medication called dexamethasone can help prevent kidney problems after heart surgery that requires a heart-lung machine, known as cardiopulmonary bypass. The goal is to see if giving patients 1 mg of dexamethasone for every kilogram they weigh during their surgery can reduce the risk of developing acute kidney injury, which can happen after such procedures.

To be eligible for this study, participants should be between 30 and 65 years old and scheduled for elective heart surgery that requires cardiopulmonary bypass. They should also have a moderate to severe health condition, as indicated by their American Society of Anesthesiologists score. However, patients who have a history of kidney issues, diabetes, or other specific health concerns, such as being on certain medications or having urgent surgery, will not be included in the trial. Those who participate can expect to receive the dexamethasone during their surgery and will be monitored closely for any kidney-related issues afterward. This research could provide valuable information on improving recovery after heart surgery.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age 30-65 years.
• • 2. Sex: Both sex.
• • 3. Patients with American Society of Anesthesiologists (ASA) score III - IV.
• • 4. Patients who were scheduled for any type of elective cardiac surgical procedure requiring cardiopulmonary bypass
• Exclusion Criteria:
• • 1. Declining to give written informed consent.
• • 2. History of allergy to the medications used in the study.
• • 3. Emergent or planned off-pump procedure
• • 4. Diabetic patients.
• • 5. Patients with recent history of AKI, or have any renal deterioration as GFR \< 80 ml/min./1.73/m2
• • 6. Patients scheduled for urgent cardiac surgery.
• • 7. Patients scheduled for ascending aortic surgery inducing deep hypothermic total circulatory arrest.
• • 8. Patients on high doses of inotropes and/or vasopressors.
• • 9. Patients with high drain(s) in the first 6 hours postoperatively.