A Novel CAR-T Combined Expression of IL-15 in the Treatment of Malignant Hematological Tumors

Launched by SHANXI BETHUNE HOSPITAL · Jan 15, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment for certain types of blood cancers, including Acute Lymphocytic Leukemia, lymphoma, and multiple myeloma that have not responded to previous treatments. The treatment involves using modified immune cells (called CAR-T cells) that have been combined with a special protein (IL-15) to help them fight cancer more effectively. The researchers aim to enroll 45 participants aged between 15 and 80 years who have specific types of blood cancers and meet certain health criteria, such as having good heart and kidney function.

If you or a family member are considering participating, you would need to sign a consent form and be willing to follow the study's treatment and testing schedule. Eligible participants should have had prior treatment for their cancer and have a life expectancy of at least three months. Throughout the trial, participants will be closely monitored for their health and any side effects from the treatment. It’s important to note that some individuals, such as those with serious heart conditions or active infections, may not be eligible to join. Overall, this study aims to explore a promising new approach to treating challenging blood cancers.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • I (or the authorized representative/legal guardian) agree and have signed an informed consent form, and am willing and capable of following the planned visits, research treatments, laboratory tests, and other research procedures;
• • Histopathological or flow cytometric diagnosis of CD19 and/or CD22, BCMA-positive hematological malignancies;
• • -≥15 years old, ≤80 years old;
• • If you meet one of the following three conditions, you can be included in the group:-Patients with recurrent or refractory hematologic malignancies treated with one standard chemotherapy regimen and one salvage regimen;-Minimal residual lesions persist after treatment with one standard chemotherapy regimen and one salvage regimen;-Patients with recurrence after hematopoietic stem cell transplantation;
• • Estimated survival ≥12 weeks;
• * Good heart, liver and kidney function:
• * Serum creatinine ≤ 1.5 mg/dL (1mg/dl=88.4umol/L); Serum ALT/AST ≤ 2.5 ULN; Total bilirubin ≤ 1.5 mg/dl (1mg/dl=17.1umol/L):
• * Cardiac ejection fraction ≥50%, cardiac ultrasound showed centropericardial effusion:
• • Eastern Oncology Collaborative Group Activity Status Score (ECOG)0-3;
• • Able to understand and voluntarily sign informed consent; If the subject is a child, the guardian will sign the informed consent.
• • If the answer to any of the above is \"no\", the subject will not be allowed to participate in this study.
• Exclusion Criteria:
• • Have a New York Heart Association (NYHA) classification \> Class III heart failure or myocardial infarction, cardiac angioplasty or stenting, unstable angina, or other clinically prominent heart disease within one year prior to signing the consent form, or have a QTC interval \>480ms at the time of screening (QTC interval is calculated using the Fridericia formula);
• • Have active GVHD, or need immunosuppressants;
• • Other malignancies were present within 5 years prior to screening, except for adequately treated cervical carcinoma in situ, basal cell or squamous cell skin cancer, and breast ductal carcinoma in situ after radical resection of local prostate cancer;
• • The presence of an active or uncontrolled infection requiring systemic treatment (except for mild genitourinary and upper respiratory tract infections) in the 7 days prior to screening;
• • If HBSAg or HbCAb positive peripheral blood hepatitis B virus (HBV)DNA is higher than the lower limit of detection, it should be excluded. If hepatitis C virus (HCV) antibody positive, peripheral blood HCVRNA positive should be excluded; (HIV) antibody-positive; -Cytomegalovirus (CMV)DNA test positive for human immunodeficiency virus; Those who test positive for Treponema pallidum specific antibody (TPPA) should be excluded;
• • Participating in another clinical trial within 4 weeks prior to the signing of the informed consent, or the signing date of the informed consent is still within 5 half-lives of the drug (whichever is longer) since the last drug used in the last clinical trial;
• • A history of severe allergy to biological products;
• • Systemic diseases that are considered unstable by the investigator: including but not -limited to severe liver, kidney, or metabolic diseases requiring medical treatment;
• • Pregnant or lactating women, and female subjects who plan pregnancy within 2 years after cell transfusion or male subjects whose partner plans pregnancy within 2 years after cell transfusion;
• • Conditions that the investigator believes may increase the risk to the subject or interfere with the test results.