Incorporating Healthy Living Strategies to Aid in Recovery After Acute Pulmonary Embolism

Launched by UNIVERSITY OF ROCHESTER · Jan 14, 2025

Keywords

ClinConnect Summary

The ERAsE-PE study is looking into whether two healthy living strategies can help people recover better after being treated for a pulmonary embolism, which is a blockage in the lungs' blood vessels. Participants in this study will follow an 8-week program while also taking prescribed blood thinners (anticoagulants). Researchers will measure the changes in how hard the heart has to work during a simple 6-minute walking test to see if these strategies make a difference in recovery.

To be eligible for this study, you need to be at least 18 years old, speak English, and have recently been diagnosed with an acute pulmonary embolism that meets specific criteria, such as showing signs of heart strain on tests. Participants should be able to walk and follow daily instructions sent via text or email. If you join the study, you can expect to be part of a supportive program aimed at improving your health and recovery after your hospital stay.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. English speaking (\>18 years old). Daily messages will be sent in English.
• 2. Acute PE with at least one of the following:
• • 1. any right ventricular enlargement or dysfunction on echocardiogram;
• • 2. CT Angiogram reporting any right ventricular enlargement; or
• • 3. elevated cardiac biomarker (NT-pro BNP or troponin above baseline). Criteria for enrollment will be included on source document.
• • 3. Rate controlled atrial arrythmias (resting heart rate \<110 beats/m) are eligible for enrollment. This includes atrial fibrillations. This is standard of care management for atrial fibrillation.
• • 4. Subjects do need to take prescribed anticoagulation.
• Exclusion Criteria:
• • 1. Pregnancy.
• • 2. Cardiac Effort \>3.5 beats/m during 6MWT.
• • 3. Resting tachycardia \>110 beats/m at hospital discharge.
• • 4. Chronic Thromboembolic Pulmonary Hypertension
• • 5. Systolic blood pressure \>180 mmHg at hospital discharge.
• • 6. Inability to walk.
• • 7. Estimated prognosis \<12 months at the time of discharge due to underlying co-morbidities (e.g., cancer).
• • 8. Advanced neurologic disease and would not be able to comply with the messages.
• • 9. Lack of access to email or text messaging 10. Inability or unwillingness to follow daily instructions.