Genetic and Clinical Characterization of Type 1 and 2 Narcolepsy in Adult and Pediatric Black and North African Populations

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Jan 15, 2025

Keywords

ClinConnect Summary

This clinical trial is focused on studying narcolepsy, a sleep disorder that causes extreme daytime sleepiness and other symptoms like sudden muscle weakness (cataplexy), sleep paralysis, and vivid dreams while awake. The researchers want to learn more about how narcolepsy presents in Black and North African individuals, as previous studies have shown that it might look different in these populations compared to Caucasians. By examining the genetic and clinical aspects of narcolepsy in these groups, the trial aims to identify new genes related to the condition, which could lead to better, more personalized treatments for people of African descent.

To participate in this study, individuals must be diagnosed with narcolepsy types 1 or 2 and be aged 6 years or older. Participants will need to provide consent, either themselves or through their parents if they are minors. Additionally, the study will include volunteers without narcolepsy from similar ethnic backgrounds to help researchers make comparisons. Participants can expect to contribute to important research that could improve understanding and treatment of narcolepsy for their communities and beyond.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Narcolepsy patients:
• • Individuals of black and North African origin diagnosed with NT1 or NT2.
• • Age ≥ 6 years
• • Clinical confirmation of narcolepsy according to the criteria of the International Classification of Sleep Disorders (ICSD-3).
• • Signature of informed consent by the adult patient or both holders of parental authority for minor patients.
• Control subjects:
• • Volunteers without pathology related to the study from the same ethnic or related groups with the aim of reaching two matched control subjects for each case.
• • Age ≥ 6 years
• • Signature of informed consent by the adult subject or both holders of parental authority for minor subjects.
• Exclusion Criteria:
• • Individuals unable to understand the protocol or unwilling to participate.