Impact of Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial

Launched by XIJING HOSPITAL · Jan 17, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating how different types of anesthesia affect the risk of postoperative delirium (a state of confusion after surgery) in older diabetic patients undergoing non-heart-related surgeries. Researchers want to find out if using a medication called propofol, instead of sevoflurane, during surgery can help reduce the chances of developing this condition in patients aged 60 and older. The study will enroll 450 participants, who will be randomly assigned to receive one of these two anesthetic drugs during their procedure.

To be eligible for the trial, participants must be 60 years or older, have diabetes, and be scheduled for elective surgery that lasts at least two hours. They should also be generally healthy enough to undergo surgery. Those with certain neurological or psychiatric conditions, severe communication issues, or who are expected to need intensive care after surgery will not be included. Participants in the trial can expect careful monitoring and support throughout their surgery and recovery, as the study aims to improve care for elderly diabetic patients and reduce confusion after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥60 years
• • Elective surgery (with an expected duration of 2 hours or more)
• • ASA grade Ⅰ-Ⅲ
• • Voluntary participation and informed consent obtained
• • Diabetes mellitus
• Exclusion Criteria:
• • Known neurological or psychiatric diseases (Parkinson's disease, depression, schizophrenia), or cognitive impairment (dementia)
• • Severe visual or auditory impairments, language barriers, or patients who cannot cooperate
• • Long-term use of sedatives, antipsychotic drugs, or long-term alcohol abuse
• • Neurosurgical patients
• • Patients who are expected to require hepatic portal blockage during surgery
• • Patients who are expected to be transferred to ICU after surgery
• • Patients with a known allergy to the drugs used in this study or those suspected of having propofol infusion syndrome