Test-retest Study With [18F]FBB in Cardiac Amyloidosis

Launched by LIFE MOLECULAR IMAGING GMBH · Jan 17, 2025

Keywords

ClinConnect Summary

This clinical trial is designed to study a special imaging test called [18F]florbetaben PET, which helps detect a condition known as cardiac amyloidosis (CA) in the heart. The researchers want to see how reliable this test is when it’s done more than once, particularly for patients with two types of cardiac amyloidosis called AL-CA and ATTR-CA, as well as for patients who do not have this condition. By comparing the test results over time, the study aims to better understand how amyloid deposits in the heart can be measured and what factors may affect these measurements.

To participate, individuals must be at least 40 years old and able to provide informed consent. This means they should understand what the study involves and agree to take part. Both men and women can join, but there are specific requirements regarding pregnancy and contraception for women. Participants will undergo the PET scans along with some blood tests, and must be in stable health, meaning they should not have received certain treatments or have specific health issues that could interfere with the study. The trial is not yet recruiting, so there is still time to learn more if you think you or someone you know may be eligible.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Inclusion criteria (for all subjects):
• • Males and females aged ≥40 years
• • Able to understand, sign, and date written informed consent
• • Written informed consent must be obtained before any assessment is performed
• • Female subjects must be documented by medical records or physician's note to be either surgically sterile (by means of hysterectomy, bilateral salpingectomy or bilateral oophorectomy) or post-menopausal for at least 1 year (no menses for 12 months without an alternative medical cause). If they are of child-bearing potential, they must commit to use of a highly effective contraceptive measure for one week after the PET scan (including combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal or transdermal), progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable or implantable), intrauterine device, intrauterine hormone-releasing system, bilateral tubal occlusion, vasectomised partner or sexual abstinence)
• • Male subjects and their partners of childbearing potential must commit to the use of a highly effective method of contraception for a minimum of 90 days following each PET scan (including, for female partners of childbearing potential, combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal or transdermal), progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable or implantable), intrauterine device, intrauterine hormone-releasing system, bilateral tubal occlusion, male subjects with vasectomy or sexual abstinence)
• • Male subjects must commit to not donate sperm for a minimum of 90 days after the PET scan
• • Medications taken for treatment of multiple myeloma or chronic diseases of the heart or tafamides treatment are maintained on a stable dosage regimen.
• • Patients on stable coagulation, if arterial blood sampling isperformed.
• * Inclusion criteria for AL-CA and ATTR-CA patients:
• • • Patients with a clinical diagnosis of cardiac AL amyloidosis or cardiac ATTR diagnosis according to diagnostic criteria
• * Inclusion criteria for control patients:
• The control subjects must meet one of the following criteria:
• • Patients without heart failure and no suspicion of cardiac amyloidosis OR
• • Patients with impaired heart function but cardiac amyloidosis ruled out by echocardiography, CMR or cardiac biopsy OR
• • Patients with known plasma cell dyscrasia (MGUS, multiple myeloma) but no clinical signs of cardiac amyloidosis detected by echocardiography or CMR
• Exclusion Criteria:
• • Subject has received, in the last 3 months, or currently receives amyloid targeting monoclonal antibody therapy.
• • Any known allergic reactions or hypersensitivity towards any compound of the study drug
• • Hemoglobin value \< 10 g/dL
• • Severe hepatic impairment (AST or ALT \>5 x ULN; bilirubin \>3 x ULN)
• • Subject receives hemodialysis or peritoneal dialysis
• • Inability to lay flat for up to 60 min
• • Pregnant, lactating or breastfeeding
• • Unwilling and/or unable to cooperate with study procedures
• • Having received a PET scan within one week before the 18F\]florbetaben PET scan
• • For patients were arterial sampling isperformed: Subject has a contraindication to arterial cannulation, including but not limited to allergy to local anesthetics, peripheral vascular disease, Raynaud's phenomenon as determined by abnormal Allen's test or abnormal coagulation profile at screening.