Effect of Supplement on Appetite and GLP-1

Launched by TEXAS CHRISTIAN UNIVERSITY · Jan 23, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating whether a dietary supplement can help reduce feelings of hunger and increase the release of a hormone called GLP-1, which helps control appetite and blood sugar levels. The supplement includes ingredients like L-arginine, resveratrol, tart cherry, and vitamin C. The study aims to find out if this supplement works better than a placebo (a non-active treatment) in people who are overweight or obese.

To participate in the study, you need to be between 18 and 60 years old and have a Body Mass Index (BMI) between 25 and 40. You’ll need to maintain your usual eating and exercise habits throughout the study. If you join, you’ll attend three lab visits where you'll take either the supplement or a placebo after fasting, eat a standardized meal, and then rate your hunger and provide blood samples to measure hormone levels. While you may not benefit directly from participating, the research could lead to new appetite-suppressing supplements in the future. The study takes precautions to minimize risks, like discomfort from blood draws or potential allergic reactions, ensuring your safety and privacy throughout the process.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Participants must meet all the following conditions to be eligible for the study:
• • Age: 18-60 years old.
• • BMI (Body Mass Index): Between 25 and 40 kg/m².
• • Diet and Activity Stability: Willing to maintain current dietary and physical activity habits for the duration of the study.
• Exclusion Criteria:
• Participants will be excluded from the study if any of the following conditions apply:
• • Recent Weight Change: Lost or gained more than 5% of body weight in the last 3 months.
• • Pregnancy or Lactation: Pregnant or breastfeeding women.
• * Medical Conditions:
• • Kidney disease (Chronic Kidney Disease or End-Stage Renal Disease).
• • Herpes simplex.
• • Uncontrolled diabetes (HbA1c \>7%).
• • Thyroid disorders or taking thyroid medications.
• • Type 1 diabetes.
• • Cushing syndrome.
• • Cirrhosis or hepatitis.
• • Chronic obstructive pulmonary disease (COPD).
• • Dementias.
• • Active autoimmune diseases (e.g., lupus, rheumatoid arthritis).
• • Crohn's disease or ulcerative colitis.
• • Celiac disease.
• * Allergies or Sensitivities:
• • Known allergies to any components of the supplement or standardized meal.
• * Medications: Currently taking any of the following:
• • Supplements or medications for weight loss.
• • Antihypertensive, antidiabetic, or antihyperlipidemic medications.
• • Erectile dysfunction medications.
• • Blood thinners (e.g., aspirin, warfarin).
• • Medications containing nitric oxide or nitroglycerin.
• • Drugs affecting GLP-1 levels, such as GLP-1 receptor agonists, insulin, certain antidepressants, or corticosteroids.
• • Substance Use: Evidence of illegal drug use, including marijuana.
• • Participation in Other Studies: Enrollment in another clinical trial that could interfere with the study outcomes.