Construction of a Psoriasis and Psoriatic Arthritis Diagnostic Model Based on Multidimensional Nail Information

Launched by SHANGHAI YUEYANG INTEGRATED MEDICINE HOSPITAL · Jan 23, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring a new way to diagnose psoriasis and psoriatic arthritis using advanced technology. Psoriasis is a long-lasting skin condition that can also affect the nails and joints, and some people with psoriasis may develop psoriatic arthritis, which causes joint pain and swelling. The goal of this study is to create a simple and non-invasive tool that can help doctors detect these conditions early, using information from patients’ nails and other health details. This is important because current methods can be subjective and uncomfortable for patients.

To participate in this trial, individuals must be aged between 18 and 80 and either have a diagnosis of psoriasis or be visiting for other skin conditions like eczema or acne, with confirmation that they do not have psoriasis. Participants will be asked to provide some health history and consent to the study. The researchers will use a technique called Raman spectroscopy, which is a non-invasive method that can analyze nail samples, along with artificial intelligence to develop this new diagnostic tool. This could lead to more accurate diagnoses and better treatment options for those affected by these conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • -
• Inclusion criteria for patients with psoriasis:
• • 1. Previous or first-time diagnosis o psoriasis; if previously diagnosed, no restrictions on prior treatments;
• • 2. Age ≥ 18 and ≤ 80 years, with no gender restrictions;
• • 3. Consent to participate in this study and sign an informed consent form.
• Inclusion criteria for non-psoriasis control subjects:
• • (1) Patients who visit for other non-psoriasis skin conditions such as eczema or acne, and are confirmed by dermatologists not to have psoriasis; (3) Age ≥ 18 and ≤ 80 years, with no gender restrictions; (4) Consent to participate in this study and sign an informed consent form.
• • -
• Exclusion criteria for patients with psoriasis:
• • 1. Those with unsuitable nail conditions for collection: patients with amputated fingers due to trauma or other reasons, and patients with any nail that is severely broken and cannot be effectively collected.
• • 2. Patients with severe mental illness or cognitive impairment, lacking personal decision-making capacity, and unsuitable for participation in clinical research.
• • 3. Patients with severe systemic diseases.
• • 4. Patients with a history of malignant tumors, as well as those with primary or secondary immunodeficiency and hypersensitivity.
• • 5. Patients whom the researchers deem unsuitable for participation in this study for other reasons.
• Exclusion criteria for non-psoriasis subjects:
• • 1. Those with unsuitable nail conditions for collection: patients with amputated fingers due to trauma or other reasons, and patients with any nail that is severely broken and cannot be effectively collected.
• • 2. Patients with severe mental illness or cognitive impairment, lacking personal decision-making capacity, and unsuitable for participation in clinical research.
• • 3. Patients with severe systemic diseases.
• • 4. Patients with a history of malignant tumors, as well as those with primary or secondary immunodeficiency and hypersensitivity.
• • 5. Patients whom the researchers deem unsuitable for participation in this study for other reasons.