A Clinical Study on the Benefits of Carbon Nanoparticles Injection Time in Patients With Thyroid Cancer.

Launched by SECOND AFFILIATED HOSPITAL OF XI'AN JIAOTONG UNIVERSITY · Jan 18, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the use of carbon nanoparticles in patients with papillary thyroid cancer who are undergoing surgery. Researchers want to find out whether injecting these nanoparticles before or during surgery can improve the detection of important glands and lymph nodes, which may help reduce complications after surgery. The goal is to better understand the best timing and method for these injections to enhance patient recovery and quality of life.

To participate in this study, patients should be adults with thyroid cancer that's less than 4 cm in size and who are scheduled for total thyroid removal surgery. They should not have had previous thyroid surgeries or certain treatments like radiotherapy or chemotherapy. Patients will undergo the carbon nanoparticle injections at different times during their treatment and will be monitored for their recovery. This study aims to gather valuable information that could lead to better treatment practices for thyroid cancer patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Preoperative pathological assessment indicated the presence of thyroid cancer with a maximum diameter of less than 4 cm.
• • Postoperative pathological evaluation confirmed bilateral thyroid cancer or lateral lymph node metastasis.
• • Vocal cord examination conducted one week prior to surgery revealed no abnormalities.
• • The patient had no history of prior thyroid surgery and required a total thyroidectomy.
• • Blood pressure was stably controlled.
• • The patient regained consciousness and was able to communicate normally.
• Exclusion Criteria:
• • Prior to enrollment, the patient had received radiotherapy, chemotherapy, or isotope therapy.
• • A documented history of thyroid surgery.
• • Age under 16 years.
• • Known allergies to the medications under investigation or an inability to tolerate surgical intervention.
• • Presence of a retrosternal thyroid tumor.
• • Tumor invasion of the parathyroid glands and/or the recurrent laryngeal nerve during surgical procedures.
• • Postoperative pathology suggestive of medullary carcinoma or undifferentiated carcinoma.
• • Development of a postoperative tracheal fistula.