A Comparative Study Between Opioids Free Anesthesia and Opioid Anesthesia in Patients with Supratentorial Tumor Resection

Launched by KASR EL AINI HOSPITAL · Jan 19, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different types of anesthesia for patients undergoing surgery to remove brain tumors located above the tentorium (a part of the brain). The trial compares traditional opioid anesthesia, which uses strong pain medications like fentanyl, with opioid-free anesthesia (OFA), which uses a combination of other medications to manage pain without opioids. Researchers want to see if OFA can provide effective pain relief while also improving recovery times and reducing side effects like nausea and the need for additional pain medications after surgery.

To be eligible for this trial, participants should be between 18 and 50 years old and in good health, classified as ASA I or II (which means they have no serious health issues). They must be undergoing surgery to remove a supratentorial tumor while lying on their back. However, individuals with certain health conditions, such as uncontrolled high blood pressure, heart problems, or those who are pregnant, cannot participate. If you join the trial, you can expect to receive either type of anesthesia during your surgery and be monitored closely by medical staff. This trial aims to find safer and more effective anesthesia options for brain surgery, which could benefit many patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. ASA Ι and II.
• • 2. Patients undergoing resection of supratentorial tumors in supine position.
• • 3. Age (18-50) years.
• • 4. Both sexes.
• Exclusion Criteria:
• • 1. Impaired renal functions.
• • 2. Uncontrolled systemic hypertension(patients with sustained elevated blood pressure more than 140/90).
• • 3. Cardiac arrhythmias (any rhythm other than normal sinus rhythm and sinus tachycardia).
• • 4. Heart failure(impaired cardiac contractility ,EF less than 45%.).
• • 5. Patients receiving more than 2 units of blood during surgery.
• • 6. Patients with large masses and expected severe increase in ICP.
• • 7. Patients requiring vasopressors infusion.
• • 8. The need for postoperative ventilation at the end of study.
• • 9. Glasgow coma scale less than 14.
• • 10. History of allergy to the study drugs.
• • 11. Surgeries lasting more than 4 hours.
• • 12. Pregnancy.
• • 13. Bronchial asthma.