Brain Blood Flow and Lactate in Non-obese and Obese Subjects

Launched by UNIVERSITY OF MISSOURI-COLUMBIA · Jan 19, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a substance called lactate, which the body produces during exercise, affects blood flow to the brain in people with and without obesity. Researchers want to understand if higher levels of lactate can improve brain health and function, especially since reduced blood flow to the brain can lead to serious issues like memory loss and conditions such as Alzheimer’s disease. The trial will also explore if short exercise sessions can help people with obesity manage their lactate levels better.

To be eligible for this study, participants should be healthy adults aged 18 to 45, with a body mass index (BMI) between 18 and 40. Women must be premenopausal and not pregnant or breastfeeding. There are some health conditions, medications, and recent health events that could prevent someone from participating, so it’s important for potential volunteers to discuss their health history with the researchers. If chosen, participants can expect to take part in exercises and tests that will help scientists learn more about the relationship between lactate, exercise, and brain blood flow.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • healthy adult men and women 18-45 years of age BMI 18-40 kg/m2 not pregnant, premenopausal with regular menstrual cycles not breastfeeding non-nicotine users
• Exclusion Criteria:
• • medications known to affect sleep, autonomic control, blood lactate levels or metabolic, or cardiovascular function (PI discretion) self-reported history of hepatic, renal, pulmonary, cardiovascular, or neurological disease, stroke or neurovascular disease, bleeding/clotting disorders, sleep apnea or other sleep disorders, diabetes, history of alcoholism or substance abuse major cardiovascular event or surgical procedure within the past three months hypertension (\>140/90 mmHg or at PIs discretion).
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