Impact of Probiotics on Gut Microbiome During Antibiotic Prophylaxis in Elective Orthopedic Surgery

Launched by ACIBADEM MASLAK HOSPITAL · Jan 18, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether probiotics, which are good bacteria that help keep our gut healthy, can help maintain a balanced gut microbiome in patients who are taking antibiotics before elective orthopedic surgeries, like knee arthroscopy or carpal tunnel release. Antibiotics are important for preventing infections after surgery, but they can also upset the natural balance of gut bacteria, leading to problems like dysbiosis. The researchers believe that taking probiotics during this time might help protect gut health and improve overall recovery.

To participate in this trial, you would need to be an adult between 18 and 65 years old and scheduled for one of the specified orthopedic surgeries. However, if you have taken antibiotics or certain supplements recently, have a history of specific health issues (like autoimmune diseases or chronic intestinal problems), or have allergies to certain antibiotics, you might not be eligible. If you join the study, you can expect to receive either probiotics or a placebo (an inactive substance) during your treatment period, and the researchers will monitor your gut health and recovery closely. This trial aims to find out if probiotics can make a real difference in keeping your gut healthy while you’re on antibiotics.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged between 18 and 65 years
• • Scheduled for elective low-risk orthopedic surgery (carpal tunnel release, A1 pulley release, knee arthroscopic surgery).
• Exclusion Criteria:
• • History of infection or antibiotic use within the last 12 weeks.
• • Use of routine probiotics, vitamins, or herbal supplements in the last 4 weeks.
• • Known allergy to beta-lactam or cephalosporin antibiotics.
• • History of autoimmune disease, uncontrolled systemic disease, or chronic inflammatory conditions (e.g., systemic lupus erythematosus, rheumatoid arthritis).
• • History of chronic intestinal diseases such as small intestine bacterial overgrowth (SIBO), irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), or celiac disease.
• • Increased risk of infection due to medical comorbidities or use of immunosuppressive drugs.