Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study

Launched by FONDAZIONE IRCCS CA' GRANDA, OSPEDALE MAGGIORE POLICLINICO · Jan 20, 2025

Keywords

ClinConnect Summary

This clinical trial is focused on understanding a kidney condition called idiopathic nephrotic syndrome, which primarily affects children. The goal is to find ways to predict how well children will respond to treatment right from the start of their illness. Many children with this condition require long-term medications to help manage their symptoms, but these treatments can come with unpleasant side effects. By studying blood and urine samples from affected children, the researchers hope to identify specific markers that can indicate how a child’s immune system interacts with their kidneys. This information could lead to more personalized treatment plans, helping to avoid unnecessary medications and their side effects.

To participate in this study, children must be between the ages of 1 and 18 and have a confirmed diagnosis of idiopathic nephrotic syndrome, which includes specific symptoms like high levels of protein in their urine and low levels of a protein called albumin in their blood. Importantly, children should not have received any previous treatment for this condition. The trial is not yet recruiting participants, but it aims to improve the overall management of nephrotic syndrome in children, ultimately striving for better health outcomes and a higher quality of life.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Clinical diagnosis of idiopathic nephrotic syndrome (INS) with nephrotic range proteinuria (uPr/uCr ratio \> 2 mg/mg).
• • Hypoalbuminemia with serum albumin \< 3.0 g/dL.
• • Presence of edema.
• • No prior treatment for idiopathic nephrotic syndrome.
• • Age between 1 and 18 years at the time of enrollment.
• • igned informed consent by a parent or legal guardian.
• Exclusion Criteria:
• • Diagnosis of congenital or infantile nephrotic syndrome (age \< 1 year).
• • Diagnosis of secondary nephrotic syndrome.
• • Presence of glomerulonephritis, autoimmune diseases, or vasculitis.
• • Lack of signed informed consent by a parent or legal guardian.
• • Previous treatment with prednisone or prednisolone for nephrotic syndrome.