MEASUREMENT of CIRCULATING MUTATION BURDEN
Launched by CENTRE FRANCOIS BACLESSE · Jan 20, 2025
Trial Information
Current as of July 01, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at how certain genetic changes, called mutations, can be measured in women who are at risk for breast and ovarian cancer due to family history. Specifically, the study will involve women who are part of sibling pairs where one sister carries a mutation linked to breast cancer (known as a BRCA mutation) and the other does not. The goal is to understand the differences in mutation burden, which may help in understanding cancer risk better.
To participate in this trial, women need to be between 30 and 50 years old, must be involved in genetic monitoring at a specific cancer center, and should be part of a sibling pair as described. Participants will need to provide their consent before joining the study. Since this trial is not yet recruiting, it’s important to keep an eye out for when it begins if you or someone you know might be interested in getting involved.
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Female participant
- • Participant undergoing oncogenetic follow-up at the Centre François Baclesse
- • Participant belonging to a pair of related biological siblings
- • Within the sibling pair, one participant is a carrier of a hereditary predisposition linked to a BRCA1/2 mutation (case), and the other participant is not a carrier (control).
- • Participant between 30 and 50 years of age
- • Participant affiliated to a social security scheme
- • Participant having given her consent to participate by signing an informed consent form prior to any specific study-related procedure.
- Exclusion Criteria:
- • -
About Centre Francois Baclesse
The Centre François Baclesse is a leading cancer research and treatment facility in France, dedicated to advancing oncology through innovative clinical trials and cutting-edge medical care. Renowned for its multidisciplinary approach, the center integrates comprehensive patient management with pioneering research initiatives, focusing on developing new therapies and improving existing treatments for various cancer types. With a commitment to enhancing patient outcomes, the Centre François Baclesse collaborates with national and international partners to contribute to the global body of knowledge in cancer treatment and research, making it a pivotal player in the fight against cancer.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Caen, , France
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported