MEASUREMENT OF CIRCULATING MUTATION BURDEN

Launched by CENTRE FRANCOIS BACLESSE · Jan 20, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how certain genetic changes, called mutations, can be measured in women who are at risk for breast and ovarian cancer due to family history. Specifically, the study will involve women who are part of sibling pairs where one sister carries a mutation linked to breast cancer (known as a BRCA mutation) and the other does not. The goal is to understand the differences in mutation burden, which may help in understanding cancer risk better.

To participate in this trial, women need to be between 30 and 50 years old, must be involved in genetic monitoring at a specific cancer center, and should be part of a sibling pair as described. Participants will need to provide their consent before joining the study. Since this trial is not yet recruiting, it’s important to keep an eye out for when it begins if you or someone you know might be interested in getting involved.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Female participant
• • Participant undergoing oncogenetic follow-up at the Centre François Baclesse
• • Participant belonging to a pair of related biological siblings
• • Within the sibling pair, one participant is a carrier of a hereditary predisposition linked to a BRCA1/2 mutation (case), and the other participant is not a carrier (control).
• • Participant between 30 and 50 years of age
• • Participant affiliated to a social security scheme
• • Participant having given her consent to participate by signing an informed consent form prior to any specific study-related procedure.
• Exclusion Criteria:
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