ASSESSMENT of FRAILTY AS a PROGNOSTIC FACTOR for MORTALITY, DISABILITY, and QUALITY of LIFE AFTER ICU ADMISSION

Launched by HOSPITAL UNIVERSITARI VALL D'HEBRON RESEARCH INSTITUTE · Jan 20, 2025

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how frailty affects older adults (those over 70 years old) who are admitted to the Intensive Care Unit (ICU). Frailty is a condition that makes individuals more vulnerable to health issues, and many elderly patients in the ICU are affected by it. The study aims to find out how frailty relates to important outcomes like survival rates, the ability to function after treatment, and overall quality of life for these patients. It is particularly looking at those who need life-support interventions, such as mechanical ventilation, for more than 24 hours.

To be eligible for this trial, participants must be elderly patients over 70 years old who are admitted to the ICU and require at least one life-support treatment for an extended period. However, individuals with certain conditions, such as having a very short life expectancy or specific neurological diseases, may not be able to participate. If you or a loved one are considering joining this study, you can expect to be closely monitored, and the research will help doctors understand better how to care for frail older adults in critical situations.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • Elderly patients over 70 years of age requiring admission to ICU-semicritical units.
• * Patients receiving at least one life-support intervention for more than 24 hours, including:
• • Mechanical ventilation (invasive or non-invasive),
• • Vasopressor or inotropic treatment,
• • Requirement for acute renal replacement therapies for more than 24 hours,
• Extracorporeal support such as:
• • Veno-Venous Extracorporeal Membrane Oxygenation (ECMO-VV), Veno-Arterial Extracorporeal Membrane Oxygenation (ECMO-VA).
• Exclusion Criteria:
• • Patients with an ICU stay of less than 72 hours.
• • Patients with treatment limitations upon ICU admission, although an isolated "Do Not Resuscitate" (DNR) order is acceptable; life expectancy of less than 6 months.
• • Absence of family members or caregivers available to provide medical history. Language barriers (non-Spanish speakers without access to medical translators).
• • Structural neurological diseases requiring ICU admission, including stroke or spinal cord pathology.
• • Patients for whom 12-month follow-up is anticipated to be unfeasible.
• • Patients without consent authorization.