Ultrasound With Subharmonic Imaging and Subharmonic Aided Pressure Estimation (SHAPE) to Identify Portal Hypertension

Launched by MAYO CLINIC · Jan 22, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to identify portal hypertension (PH), which is high blood pressure in the vein that carries blood to the liver. The researchers are testing a special ultrasound technique called subharmonic imaging along with a method known as SHAPE, which can estimate blood pressure without needing a painful procedure like catheterization. Early detection of PH is important because it can lead to serious complications, so finding a noninvasive method could help doctors diagnose and monitor this condition more easily.

To participate in the study, you need to be an adult (18 years or older) who can give informed consent. If you are a woman who can become pregnant, you must have a negative pregnancy test. You also need to be scheduled for a standard pressure measurement procedure. However, if you are pregnant, nursing, or have certain allergies, you would not be eligible. Participants can expect to undergo the new ultrasound technique and may help improve how doctors identify and manage portal hypertension in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Provide signed and dated informed consent form
• • Willing to comply with all study procedures
• • Adult patients (age of 18 years or older)
• • If a female of child-bearing potential, must have a negative pregnancy test
• • Be scheduled for HVPG measurement
• Exclusion Criteria:
• • Patients who are unable to provide consent
• • Females who are pregnant or nursing
• • Patients with known or suspected hypersensitivity to perflutren lipid microsphere or its components, such as polyethylene glycol (PEG)