Biochemical, 2D and 3D Ultrasonographic Predictors of Pregnancy Outcome in Women With Threatened Abortion

Launched by CAIRO UNIVERSITY · Jan 27, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how certain ultrasound measurements can predict the outcome of pregnancies in women experiencing a threatened miscarriage, which is when there is vaginal bleeding or abdominal pain but a live embryo is still visible on an ultrasound. The researchers will use both 2D and 3D ultrasound techniques to take measurements at the beginning of the study, again after 1 to 2 weeks, and finally at the end of the 12th week of pregnancy. The goal is to understand how these measurements can help determine whether the pregnancy is likely to continue or not.

To be eligible for this trial, participants should be women aged 19 to 39 years, with a healthy body mass index (BMI) between 18 and 25, and they should be in the early stages of a singleton pregnancy (meaning just one baby) between 6 to 11 weeks. Participants will undergo several ultrasound exams and will be monitored closely throughout the study. It's important to note that women with certain health conditions or complications, such as uterine abnormalities, chronic diseases, or those who have received fertility treatments, will not be eligible to join. This study is currently recruiting participants, and it could provide valuable insights for managing threatened miscarriages in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Age 19 -39 years
• • BMI 18-25 kg/m2
• • Singleton pregnancy between 6 to 11 gestational weeks of pregnancy.
• • First trimester threatened abortion is usually diagnosed in women with history of vaginal bleeding or spotting and/or abdominal pain in whom a live embryo can visualized on scan
• • Gestational age (GA) calculated by the last menstrual period date (LMP) in women with sure dates and regular menstrual cycles and confirmed by transvaginal sonography performed up to the 11th gestational week, using the crown-rump length
• Exclusion Criteria:
• • Uterine malformations or pathology as submucous myoma
• • Cervical abnormalities as polypi or severe chronic cervicitis
• • Chronic medical conditions as uncontrolled diabetes or hypertension
• • Smoking or drug abuse during this pregnancy
• • Pregnancies resulting from infertility treatments and assisted reproductive techniques.
• • Women with exogenous progesterone support
• • Use of abortion induction drugs\\
• • First trimester vaginal bleeding or spotting and/or abdominal pain and diagnosed by ultrasound as missed (absence of cardiac activity within fetal pole), incomplete (endometrial thickness between 5 to 15 mm), complete (thin and regular endometrium), anembryonic (gestational sac without a detectable fetal pole) and ectopic (+ve pregnancy test with empty gestational sac