Comparison of the Efficacy of Chemical Genicular Nerve Neurolysis Using Alcohol or Phenol Versus Radiofrequency Ablation Under Ultrasound Guidance for Pain Management in Patients With Knee Osteoarthritis

Launched by TANTA UNIVERSITY · Jan 28, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different methods to help manage chronic knee pain in patients with knee osteoarthritis, which is a condition that causes pain and stiffness in the knee joint. The trial will compare the effectiveness of “chemical genicular nerve neurolysis” using alcohol or phenol (which are substances that can help block pain signals) against “radiofrequency ablation” (a technique that uses heat to disrupt pain signals) to see which method provides better pain relief and improves knee function over time.

To be eligible for the trial, participants must be over 18 years old and have moderate to severe knee pain that has lasted for more than six months, despite trying other treatments like medications or physical therapy. Participants will receive one of the two treatments and will be monitored for pain relief and knee function at various times after the procedure, including immediately after, and again at one week, one month, three months, six months, and one year. It's important to know that certain patients, such as those who have had recent knee injections or surgeries, may not qualify for this study. This trial aims to find safer and more effective ways to help those suffering from debilitating knee pain.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The following will be the criteria for inclusion, (105) patients older than 18 years with moderate to severe knee pain due to knee osteoarthritis (pain of intensity six or more on a numeric rating scale \[NRS\], persistent pain for more than six months, grade III or IV osteoarthritis in the radiological Kellgren-Lawrence (KL) classification (5-11), and failure to manage pain with conservative methods such as analgesics, intra-articular injection, and physical therapy.
• Exclusion Criteria:
• • • Patients' refusal to participate in the study.
• • History of intra-articular injection within three months before or after the procedure.
• • Coagulopathy and anticoagulant use.
• • Systemic disease as: renal or hepatic insufficiency.
• • Unable to communicate with the patient.
• • Implantable device.
• • Previous knee surgery.
• • Knee pain due to causes other than knee osteoarthritis (such as meniscopathy, trauma, spine disorder).