CSS-SR Validation Study
Launched by HOSPITAL FOR SPECIAL SURGERY, NEW YORK · Jan 27, 2025
Trial Information
Current as of June 27, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
Complex Regional Pain Syndrome (CRPS) is a chronic pain condition characterized by spontaneous pain, allodynia and hyperalgesia, edema, vasomotor and sudomotor changes, and motor and trophic changes. It usually begins regionally in a single limb after injury or surgery, and inflammatory, autonomic, and central mechanisms all appear to contribute to differing degrees. There are currently no treatments for CRPS proven effective in large scale clinical trials.
CRPS is considered an orphan condition by the U.S. Food and Drug Administration, and as such, acquiring adequate sample sizes for defi...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 18 years of age or older
- • Suspected or diagnosed with unilateral CRPS type I or II of the upper or lower extremity
- • Suspected or diagnosed with non-CRPS-related pain of the upper or lower extremities
- Exclusion Criteria:
- • Bilateral CRPS
- • Total knee arthroplasty as the inciting event of CRPS
- • Less than 18 years of age
- • Non-English speaking
- • Inability to comprehend study protocol and questionnaires
About Hospital For Special Surgery, New York
The Hospital for Special Surgery (HSS) in New York is a world-renowned institution specializing in orthopedic surgery, rheumatology, and rehabilitation. Recognized for its commitment to advancing medical research and improving patient outcomes, HSS serves as a leading clinical trial sponsor, facilitating innovative studies that explore cutting-edge treatments and therapies. With a team of expert clinicians and researchers, HSS aims to enhance clinical practices through rigorous scientific inquiry, ultimately contributing to the advancement of musculoskeletal health and patient care on a global scale.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
New York, New York, United States
Patients applied
Trial Officials
Alexandra Sideris, PhD
Principal Investigator
Hospital for Special Surgery, New York
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported