The Effect of Colchicine on the Occurrence of Atrial Fibrillation After Cardiac Surgery

Launched by TOMSK CARDIOLOGY RESEARCH INSTITUTE · Jan 22, 2025

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ClinConnect Summary

This clinical trial is studying whether a medication called colchicine can help prevent a heart rhythm problem known as atrial fibrillation in patients who are having heart surgery. Specifically, the trial will involve 140 patients who are scheduled for a procedure called coronary artery bypass grafting (CABG). Half of the participants will receive colchicine during their recovery, while the other half will receive standard pain relief medications. Researchers hope that colchicine can reduce the chances of developing atrial fibrillation after surgery, which can lead to complications.

To participate in this trial, individuals must be between 65 and 74 years old and scheduled for elective CABG surgery with the use of a heart-lung machine. They need to provide informed consent, meaning they agree to take part in the study after understanding what it involves. However, there are some health conditions that would exclude someone from joining, such as severe heart or liver issues, existing atrial fibrillation, or a previous heart device like a pacemaker. Participants can expect close monitoring during their hospital stay and will be part of a study that aims to improve recovery after heart surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Elective coronary artery bypass grafting on pump;
• • 2. signed informed consent to participate in the study.
• Exclusion Criteria:
• • 1. Reduced left ventricular ejection fraction (≤35%);
• • 2. Valvular heart disease requiring surgical correction;
• • 3. Liver failure with an increase in liver transaminases ≥1.5 times;
• • 4. Renal failure (GFR\<35 mL/min/1.73 m2 calculated with CKD-EPI);
• • 5. Permanent, persistent or paroxysmal atrial fibrillation;
• • 6. Previously implanted pacemaker;
• • 7. Hypersensitivity to colchicine;
• • 8. Neutropenia;
• • 9. History of alcoholism;
• • 10. Refusal to sign informed consent