Assessments of Metabolic Responses to Acute Oral Administration of Sucrose, Glucose, and Fructose

Launched by UNIVERSITY HOSPITAL, BASEL, SWITZERLAND · Jan 23, 2025

Keywords

ClinConnect Summary

This clinical trial is designed to study how our bodies react to three different types of sugars: sucrose, glucose, and fructose. Researchers want to see how these sugars affect various aspects of our metabolism, including hormones that help regulate appetite and digestion, as well as blood sugar control and overall health indicators. They hope to learn more about how these sweeteners influence how we feel hunger and how our bodies process food.

To participate in this study, you need to be a healthy adult aged 18 to 55, with a normal weight and stable body weight for at least three months. You should not have diabetes or specific dietary restrictions, and you must be able to give your consent to take part. If you join the study, you will take one of the sugars and then be monitored for different metabolic responses, which might include how quickly your stomach empties and any changes in your appetite. It's a great opportunity to contribute to important research while learning more about how sweeteners affect health!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy, non-diabetic (glycated hemoglobin (HbA1c) \< 5.7%, fasting glucose \< 5.6 mmol/L), and normal weight participants with a body-mass index (BMI) of 19.0-24.9 kg/m2, parameters of complete blood count within normal range
• • Age 18-55 years
• • Stable body weight (± 5%) for at least three months
• • Able to give informed consent as documented by signature
• Exclusion Criteria:
• • Fructose intolerance
• • Any pre-existing diet (e.g., vegetarian diet, vegan diet, sugar free diet, paleo diet, Atkins diet, ketogenic diet) that deviates from normal eating habits
• • Regular consumption (\>1/ week) of erythritol or xylitol
• • Regular intake of medications, except contraceptives
• • Pre-existing impairment of blood coagulation/thrombocyte function (e.g. hereditary, regular intake of anti-coagulant agents (e.g. NSAIDs, heparin, warfarin, etc.))Chronic or clinically relevant acute infections/diseases
• • Substance abuse (more than 1 glass wine/beer per day; regular consumption of cannabis, consumption of cocaine, heroin, etc.), regular smoking
• • Pregnancy: although no contraindication, pregnancy might influence metabolic state. Women who are pregnant or have the intention to become pregnant during the course of the study are excluded. In female participants a urine pregnancy test is carried out upon screening.
• • Shift worker
• • Participation in another study with investigational drug within the 30 days preceding and during the present study