Dysregulation of Whole-body Metabolism in Ovarian Cancer: A Longitudinal Study

Launched by UNIVERSITY OF TENNESSEE GRADUATE SCHOOL OF MEDICINE · Jan 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how ovarian cancer affects the body’s overall metabolism, particularly focusing on how the body processes fats before, during, and after treatment. Researchers want to understand these changes better because there isn’t much information available on this topic for ovarian cancer patients. The study involves women who are at least 18 years old and are being treated for ovarian cancer, specifically those who will undergo surgery followed by chemotherapy.

If you decide to participate, you will attend several study visits where you will have your metabolism tested using a method called indirect calorimetry. This involves measuring how your body uses energy, both when you’re fasting and after eating. To be eligible, you need to be available for all visits, have internet access, and be able to communicate easily. However, if you are pregnant or have certain medical conditions that could make it hard to follow the study's requirements, you may not be able to participate. This study aims to gather important information that could help improve the care of future ovarian cancer patients.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women
• • Age \>18
• • Presumed ovarian cancer diagnosis (i.e. those being clinically evaluated for suspicion of ovary cancer)
• • Planned treatment course for ovarian cancer involving cytoreductive surgery followed by chemotherapy
• • Availability to commit to attending all study visits
• • Internet access and consistent access to phone/email/text communication
• Exclusion Criteria:
• • Pregnancy
• • Inability to provide voluntary informed consent
• • Inability to consume the pre-study visit meal/snack and/or the study visit meal due to strict dietary restrictions
• • Illicit substance use (e.g. cocaine, methamphetamines, heroin, street drugs) - marijuana and CBD oil and related supplements will be considered on a case-by-case basis by the principal investigators
• • Circumstances and/or medical condition that would limit compliance with study requirements and protocol, as determined by the principal investigators