Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery

Launched by UNIVERSITY OF EDINBURGH · Jan 28, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the outcomes of coronary artery bypass graft (CABG) surgery, particularly focusing on why some patients experience graft failure or complications like heart attacks and strokes after the surgery. Researchers will use a special imaging technique called a total-body PET scan to see what’s happening inside the vein grafts, as well as how the heart and other parts of the body are affected after the surgery. The goal is to better understand these issues and improve treatment options for patients.

To participate in this study, you need to be over 18 years old and fall into one of two groups: either you’ve recently had CABG surgery and received at least one vein graft, or you had CABG surgery at least five years ago and are experiencing symptoms that suggest your vein grafts may not be working well. The study will last three years and involve several assessments, including scans and blood tests. If you’re interested, it’s important to know that there are specific health conditions that might exclude you from participating, such as severe kidney problems or being on certain medications. Overall, this trial aims to provide valuable insights into the long-term effects of CABG surgery.

Gender

ALL

Eligibility criteria

• INCLUSION CRITERIA:
• • Cohort 1: Patients undergoing CABG surgery
• • Males and females over 18 years of age
• • Patients undergoing CABG surgery for multivessel coronary artery disease, who receive at least one saphenous vein graft
• • Cohort 2: Patients with symptomatic saphenous vein graft vasculopathy
• • Males and females over 18 years of age
• • Patients who underwent CABG surgery ≥ 5 years prior to recruitment for multivessel disease and received 2 or more saphenous vein grafts
• • Referred for invasive coronary angiography due to recurrent symptoms and with a high suspicion of graft vasculopathy
• EXCLUSION CRITERIA:
• • Patients with a life expectancy of \< 2 years
• • Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2)
• • Patients on immunosuppressive therapies
• • Females of child-bearing age who are pregnant or breastfeeding,
• • Known allergy or contraindications to iodinated contrast or radiotracer
• • Patients who are unable to tolerate the supine position
• • Patients who are unable to provide informed consent