Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production

Launched by UNIVERSITY OF COLORADO, DENVER · Jan 29, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new device called Smart Underwear, which aims to measure how our diet affects the production of a gas called hydrogen sulfide (H₂S) in our gut. Hydrogen sulfide is produced by bacteria in our intestines, and it can be influenced by what we eat. In this study, participants will follow two different diets over a couple of weeks—one diet will have a lot of a substance called cysteine, while the other will have very little. Participants will be healthy adults aged 18 and older, who have regular bowel movements and can commit to eating all the provided meals throughout the study.

If you choose to participate, you can expect to follow these two specific diets while wearing the Smart Underwear, which will track changes in your body. The study is looking for individuals who don’t have major health issues, like diabetes or heart disease, and who don’t have dietary restrictions that would prevent them from completing the study. It's important to note that you need to be able to discuss your experiences, including any gas (flatus) produced during the study, as this is part of the research. Overall, this trial aims to help researchers better understand the connection between diet and gut health, which could lead to more personalized nutrition advice in the future.

Gender

ALL

Eligibility criteria

• • The inclusion/exclusion criteria will identify generally healthy volunteers that are able to ingest the intervention diets. Exclusion criteria based on diseases, medications, allergies, and specific dietary requirements will minimize the risks of adverse reactions to the intervention diets.
• Inclusion Criteria:
• • Generally healthy volunteers defined as having no major known health conditions (e.g., diabetes, cancer, hypertension, etc.).
• • Normal bowel movements, with approximately 1 bowel movement reported per day
• • Willing to discuss flatus
• • Ages \>18yrs
• • Willing to complete the entire study protocol, i.e. eating all of the food that is provided and completing all required measurements.
• Exclusion Criteria:
• • Self-report or other evidence of diabetes, other endocrine/metabolic abnormality, dyslipidemia, morbid obesity, severe hypertension, chronic kidney disease, liver disease, pulmonary disease, gastrointestinal, and cardiovascular diseases
• • Chronic medications for any of the above conditions
• • Food allergy that interferes with ability to complete the study
• • Food preferences, intolerance, or dietary requirements that would interfere with diet adherence
• • Planned dietary changes during the study period
• • Lack of appropriate food refrigeration and preparation equipment (e.g.- oven or microwave)
• • Pregnancy or planned pregnancy in the next month
• • Physical measurements: BMI \> 35 kg/m2