Study of Tamsulosin, Solifenacin and Mirabegron in Alleviating Ureteral Stent-related Symptoms

Launched by BIR HOSPITAL · Jan 27, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of three different medications—Tamsulosin, Solifenacin, and Mirabegron—in relieving symptoms caused by ureteral stents. Ureteral stents are small tubes placed in the urinary tract to help with urinary flow, but they can sometimes cause discomfort or other issues. This trial aims to compare how well these medications can help manage those symptoms in patients who have recently had certain types of kidney stone surgeries.

To be eligible for the study, participants should be adults between the ages of 19 and 80 who have had a specific kind of surgery for urinary tract stones that involves placing a stent. However, certain medical conditions or medications can disqualify someone from participating. If chosen for the trial, participants will take one of the medications and be monitored to see how well it helps with the symptoms related to the stent. This research is important because it can lead to better treatment options for patients experiencing discomfort from ureteral stents.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Eligible participants were adult patients (aged 19-80 years) who underwent unilateral retrograde rigid ureteroscopy (URS) or retrograde intrarenal surgery (RIRS) with planned ureteric stent insertion for urinary tract stones
• Exclusion Criteria:
• • Concomitant use of a-blockers, anticholinergics, corticosteroids, calcium channel blockers, and analgesics
• • Undergoing percutaneous nephrolithotomy, open ureteric surgery or laparoscopic ureteric surgery, including ureterolithotomy
• • Neurogenic bladder, Over Active Bladder (OAB) syndrome, and neurological and psychiatric diseases
• • Preoperative febrile Urinary Tract Infection (UTI)
• • Pregnancy or breastfeeding;
• • A single kidney
• • Moderate or severe cardiovascular or cerebrovascular disease
• • Hepatic dysfunction
• • History of pelvic surgery or irradiation
• • History of bladder or prostate surgery
• • Other acute medical conditions (including acute pancreatitis, acute gastroenteritis, musculoskeletal disorders) that might influence the Ureteral Stent Symptom Questionnaire(USSQ) pain score
• • Allergy to any medication