Induction of Labor - Comparison Propess with Prostaglandin E2 Vaginal Gel and Balloon Catheter

Launched by HAEMEK MEDICAL CENTER, ISRAEL · Jan 28, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different methods for inducing labor in pregnant women who are at term (37 weeks or more) and have a single baby. The trial aims to compare the effectiveness of a medication called Propess, which is placed in the vagina to help soften the cervix, with a combination of a vaginal gel and a balloon catheter. The main goal is to find out which method helps women go into labor and deliver their babies more quickly.

To participate in this study, women need to be at least 18 years old, have a Bishop score of less than 5 (which means their cervix is not yet ready for labor), and not have any health issues that would prevent them from using either treatment. Participants will be monitored to see how long it takes from the start of treatment until delivery. It’s important to note that this trial is not yet recruiting participants, but it will provide valuable information on labor induction methods for future expectant mothers.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Pregnant women at term (37 weeks of gestation or more) with singleton
• • pregnancies that are intended for IOL.
• • Initial bishop score \<5
• • No contraindications to receive either treatment.
• • Women who will give informed consent to be included in the study.
• • Women at or over the age of 18.
• Exclusion Criteria:
• • Women with a known hypersensitivity or contraindications to Propess / PGE2.
• • Parity 5 or more
• • Labor contractions more than 4 in 20 min
• • Glaucoma
• • History of previous uterine surgery
• • Hypersensitivity to prostaglandins
• • Vaginal delivery is contraindicated
• • Active cardiac, renal, pulmonary, or hepatic disease
• • Severe asthma or pulmonary disease