Is Intraoperative PTH Monitoring Obsolete in Times of Choline PET/CT? a Prospective Multicenter Cohort Study to Determine Whether the Regular Preoperative Use of Choline-PET/CT Scan Obviate the Need for Intraoperative PTH-measurement in Patients with Primary Hyperparathyreoidism

Launched by UNIVERSITY OF ZURICH · Jan 27, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether a special imaging test called Choline-PET/CT can replace the need for measuring a hormone called PTH during parathyroid surgery for patients with primary hyperparathyroidism (pHPT). In many cases of pHPT, only one of the four parathyroid glands is causing the problem, and identifying this gland can help make surgery safer and quicker. Currently, doctors often check PTH levels during surgery to see if the affected gland has been successfully removed, but this can prolong the surgery by 30 to 60 minutes. The goal of this study is to find out if using Choline-PET/CT beforehand is accurate enough to skip the PTH measurement, potentially speeding up surgeries and reducing costs.

To be eligible for the trial, participants must have pHPT and undergo a Choline-PET scan before surgery, along with the standard PTH measurement during the operation. The study is open to all adults, and it has not started recruiting participants yet. If you decide to participate, you can expect to undergo the Choline-PET/CT scan and then have surgery, where your doctors will monitor your condition closely. This research could help improve how surgeries are performed for pHPT patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • pHPT, preoperative Choline-PET, intraoperative PTH
• Exclusion Criteria:
• • no consent