Clinical Efficacy of Platelet Transfusion

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE BESANCON · Jan 28, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how the storage time of platelet concentrates affects the risk of bleeding in patients with blood disorders, specifically those with low platelet counts (thrombocytopenia) due to their illness or its treatment. Platelets are crucial for blood clotting, and this study aims to understand if fresher platelets lead to better outcomes during transfusions, which are given to help prevent bleeding.

To participate in this study, patients must be between 65 and 74 years old and have a severe low platelet count caused by a blood disorder or bone marrow failure. They should also be able to recognize and report any bleeding they experience. However, certain patients, such as those with specific types of leukemia, those on certain medications, or those with recent significant bleeding, will not be eligible. Participants will be part of an important effort to improve transfusion practices and may help inform future treatments for people facing similar health challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with haematological malignancies or bone marrow aplasia with severe thrombocytopenia due to bone marrow failure related to the disease or treatments received
• • Severe thrombocytopenia requiring transfusion
• • Patient able to self-assess bleeding events
• • Non-opposition of the subject to participate in the study
• • Registered with the French social security system or benefiting from such a system.
• Exclusion Criteria:
• • Acute promyelocytic leukaemia
• • Curative dosage of anticoagulants
• • Treatment with antiplatelet agents
• • Patient with proven thrombocytopenia of immunological origin, or disseminated intravascular coagulation
• • Patients with a clinically significant haemorrhagic event (WHO grade 2) in the 48 hours prior to transfusion
• • Indication for deplasmatised, cryopreserved and reduced-volume PCs
• • Patient refusing transfusion of labile blood products
• • Pregnant women or breast-feeding mothers
• • Adults subject to a legal protection measure or unable to express their consent
• • Persons deprived of their liberty by a judicial or administrative decision; persons under compulsory psychiatric care; persons admitted to a health or social care institution for purposes other than research
• • Subject in the exclusion period of another study