Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation

Launched by PETROVSKY NATIONAL RESEARCH CENTRE OF SURGERY · Jan 29, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how surgical treatment for aortic regurgitation (a condition where the heart's aortic valve doesn't close properly) affects the heart's left ventricle, which is the main pumping chamber of the heart. The researchers believe that correcting a related issue called functional mitral regurgitation (when the mitral valve also doesn’t function well) during the surgery may help the left ventricle recover better after the operation. They will use ultrasound (echocardiography) to monitor heart function and quality of life in patients who have significant enlargement of their left heart chambers.

To be eligible for this trial, participants need to be over 18 years old and scheduled for surgery to fix chronic aortic regurgitation. They must also have functional mitral regurgitation and a specific size of the left ventricle. However, those with certain heart conditions, recent heart attacks, or other complications may not be able to participate. If you join the study, you can expect to have regular heart assessments after your surgery to see how well your heart is healing and functioning.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age over 18 years
• • Planned primary elective surgery for chronic aortic regurgitation
• • Presence of functional mitral regurgitation
• • End-diastolic volume of the left ventricle \>= 250 ml
• Exclusion Criteria:
• • Infectious endocarditis
• • History of myocardial infarction
• • Indications on simultaneous myocardial revascularisation
• • Acute aortic regurgitation of any etiology
• • Previously diagnosed dilatation of the left ventricle, not associated with the development of aortic regurgitation
• • Long-term persistent or permanent form of atrial fibrillation
• • Pregnancy in the first 12 months after surgery
• • Simultaneous participation in other studies
• • Presence of implanted pacemakers
• • Refusal to sign informed consent
• • Acute coronary event diagnosed within 12 months after aortic valve surgery
• • Indications for resynchronization therapy or permanent right ventricular pacing in the first 12 months after aortic valve surgery
• • Re-do cardiac surgery for any reason within 12 months after aortic valve surgery