Dixon MRI Imaging Histology for Predicting Postoperative Infection in Posterior Lumbar Fusion for Myasthenia Gravis

Launched by THE FIRST PEOPLE'S HOSPITAL OF YUNNAN · Jan 28, 2025

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ClinConnect Summary

This clinical trial is looking at how a special type of MRI called Dixon MRI can help predict the risk of infections after surgery for patients with myasthenia gravis who are undergoing a procedure known as posterior lumbar fusion. This surgery is often needed for issues in the lower back, but it can come with risks, especially if a patient has a condition called sarcopenia, which means they have less muscle mass and strength. The researchers believe that by using Dixon MRI imaging, they can get a better understanding of a patient’s muscle condition, helping to identify those who might be at higher risk for infections after their surgery.

To participate in this study, patients must be at least 18 years old and have had a Dixon MRI scan within two weeks before their surgery. They should also have sarcopenia as defined by specific medical guidelines and should be able to give their consent to participate. However, individuals with certain health issues, like serious heart or kidney problems, or those who cannot undergo an MRI due to implanted devices, will not be eligible. If you decide to participate, you can expect close monitoring and detailed follow-up after your surgery, as the researchers aim to improve safety and outcomes for patients undergoing this type of procedure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male and female patients over 18 years of age.
• • Inclusion of patients with sarcopenia is subject to the definition and diagnostic criteria of the European Consensus on Definition and Diagnosis of Sarcopenia.
• • The patient underwent posterior lumbar fusion and had a Dixon MRI scan within 2 weeks prior to surgery.
• • Patients were able to understand the purpose and procedures of the study and were willing to sign an informed consent form.
• • The patient's clinical consultation and follow-up information was complete.
• Exclusion Criteria:
• • The patient has contraindications to MRI, such as implanted metal devices (e.g., pacemakers) or severe claustrophobia.
• • Patients with serious other medical conditions, such as heart disease, kidney disease or liver disease, which may affect their post-operative recovery.
• • Patients have known immune system disorders or are on immunosuppressive therapy, which may affect their risk of infection.
• • The patient has had other spinal surgery within the last 6 months.